Shanghai Medicilon Inc.

  The intestine is the largest digestive and immune organ of animals, and it is also the site with the largest number and variety of microorganisms. Intestinal microorganisms have a close interaction with the host. On the one hand, the host provides a stable growth environment for intestinal microorganisms; on the other hand, intestinal microorganisms can help the host digest food, resist pathogenic bacteria, and produce short-chain fatty acids (short-chain fatty acids). Metabolites such as chain fatty acids (SCFAs), bile acids, and vitamins, thereby regulating the host's physiological health and affecting disease development. This article mainly reviews the composition and distribution of intestinal microorganisms in piglets, the types and functions of intestinal microbial metabolites, and the impact of probiotics on the composition and function of intestinal microorganisms in piglets, with a view to providing insights into the research on intestinal microorganisms and diseases i

Background The global prevalence of metabolic diseases such as obesity, non-alcoholic fatty liver disease (NAFLD), insulin resistance, type 2 diabetes mellitus (T2DM), atherosclerosis (AS) and polycystic ovary syndrome (PCOS) has increased dramatically . Over the past few decades, the consumption of high-calorie foods has increased and physical activity has been replaced by sedentary activities, ultimately resulting in energy intake exceeding energy expenditure and becoming a major risk factor for obesity and obesity-related diseases. In this condition, adipose tissue exceeds the body's ability to store all excess energy in the form of triglycerides, causing lipids to overflow into the circulation. This excess recruitment of lipids in non-disaccharide tissues results in ectopic fat storage, in which the ability of non-adipose tissue to increase fat oxidation upon increased fatty acid utilization is impaired. Excessive accumulation of fat in adipocytes can trigger increased produc

 To better understand the potential impact of gut microbes on human health, clinicians need to know not just the bacteria present in stool samples, but also the metabolites such as amino acids produced by those bacteria, say Australian and British researchers. The findings were published this week in the journal mSphere.       Dr Geraint B. Rogers, associate professor of microbiology and infectious diseases and member of the South Australian Institute of Health and Medical Research, said: "Typical DNA-based studies of the human microbiome or bacterial composition are limited because they do not reflect the metabolism of microbial colonies. Products. Studying the microbiome and its metabolites (metabolome) should be complementary, but because many microorganisms play the same role and some utilize the metabolites of other microorganisms, predicting metabolites is very challenging." The MetID team of Medicilon is composed of experienced scientists. We provide fast and r

Over the past 15 years, numerous studies have linked obesity, type 2 diabetes (T2DM), and cardiovascular disease to specific changes in gut microbiota composition and function. However, most studies focus on fatty acids (such as short-chain fatty acids), and some involve sugar, dietary fiber, prebiotics, etc. Over the past 5 years, it has been documented that microbial conversion of some food components such as carnitine, choline, or lecithin to produce trimethylamine N-oxide (TMAO) promotes atherosclerosis in rodent models. occurrence and is closely related to increasing the risk of cardiovascular disease in humans (Figure 1).       Based on these data, metabolites produced by microorganisms are considered to be key metabolic regulators that can affect different organs throughout the body and ultimately produce a range of beneficial or harmful functions. In addition to TMAO, which may be a potential key molecule, other microbial metabolites, such as aromatic amino acids, may a

  Metabolite identification and structure identification have wide applications in many fields, including biomedicine, drug development, environmental monitoring, etc. This article will introduce the aspects of sample collection, separation and purification, detection and identification, structural analysis, biological function research, biomarker discovery, drug development and environmental monitoring for metabolite identification and structure identification. The MetID team of Medicilon is composed of experienced scientists. We provide fast and reliable in vivo and in vitro MetID and reactive metabolite capture services. We also support new drug screening and domestic and oversees IND filings. Since the establishment of MetID team, Medicilon has successfully completed multiple different types of research projects for clients, including challenging peptide MetID research. 1. Sample collection The first step in metabolite identification and structure characterization is to collec

Metabolite identification is an important research direction in the field of biomedicine. Through the detection and analysis of metabolites in organisms, we can understand the metabolic status of organisms and the occurrence and development process of diseases, and provide strong support for disease diagnosis and treatment. The MetID team of Medicilon is composed of experienced scientists. We provide fast and reliable in vivo and in vitro MetID and reactive metabolite capture services . We also support new drug screening and domestic and oversees IND filings. Since the establishment of MetID team, Medicilon has successfully completed multiple different types of research projects for clients, including challenging peptide MetID research. The following are some common methods for metabolite identification: 1. High performance liquid chromatography (HPLC): It can separate and detect small molecule metabolites in biological samples, and is often used for the detection of metabolites su

  Related definitions After drugs enter the body, they generally undergo physical changes and chemical changes. Physical changes refer to the binding reaction between drugs and biological macromolecules such as plasma proteins; chemical changes refer to metabolic reactions in the body. Metabolic reactions in the body are also called biotransformations, which are divided into one-phase metabolism and two-phase metabolism. Phase one metabolism refers to the oxidation reaction, reduction reaction, and hydrolysis reaction of the drug in the body. Phase two metabolism refers to the conjugation reaction of drugs in the body, including: glucuronic acid conjugation, sulfation, methylation, acetylation, amino acid conjugation, glutathione conjugation, etc. The MetID team of Medicilon is composed of experienced scientists. We provide fast and reliable in vivo and in vitro MetID and reactive metabolite capture services . We also support new drug screening and domestic and oversees IND filings

  Introduction Metabolite identification is a method of analyzing metabolic products in an organism to understand its metabolic process, physiological state, and disease development. Metabolites refer to compounds formed due to metabolic processes in organisms, including organic acids, amino acids, sugars, lipids, etc. Qualitative and quantitative analysis of these metabolites can reveal the activity of different metabolic pathways in organisms, identify new physiological indicators and disease markers, and provide a basis for drug development and clinical diagnosis. Metabolite Analysis Technology Liquid Chromatography-Mass Spectrometry (LC-MS) Liquid chromatography-mass spectrometry is currently one of the most commonly used metabolite analysis techniques. It combines liquid chromatography and mass spectrometry technology to achieve highly sensitive and highly selective detection and quantification of various compounds in complex samples. In LC-MS analysis, the sample is firs