Cell Viability Assay

In vitro biological activity detection is a mandatory item for clinical application of biological products, with high requirements for method development, personnel operation stability, and laboratory compliance management. Medicilon's cell viability assay platform can provide compliant in vitro cell viability detection services that meet the application requirements. Our high-level scientific research team can assist customers in participating in new drug development and exploring drug action mechanisms, while our high-throughput screening platform can help customers conduct efficient drug screening.

Empowering new drug development

Wide variety
Medicilon offers over 400 kinds of cell models, providing detection services and functional assay services for various signal pathways.
Various Methods
Cell viability assaysReporter gene assaysTR-FRETFACSRadioactive assaysmRNA and protein expression level detection
Sample provision
Customers only need to provide compounds of the target point to be tested, and we will arrange corresponding detection services and provide professional analysis reports (specific experimental cycle depends on the experiment content).

Test Content

Test items

Test content

Antibody-Mediated Immune Cell Functional Assay

ADCC, CDC, ADCP and ADC inernalization assay.

Cell Viability Assay

Cell proliferation, growth inhibition, cytotoxicity

Cell-based radiometric assay

Isotope-based binding, uptake and proliferation assays.(H3,P32,S35,I125,C14)

ELISA

Cytokine release, Necroptosis assay

FACS assay

T cell/B cell activation and proliferation assay, T cell killing, Binding/Blocking assay, cell cycle analysis, signaling pathway activation.

GPCR assay

GLP-1R/GCGR/GIPR/GLP-2R, HTRF/Reproter Assay/Calcium Influx

Immunoblot Analysis

Protein Phosphorylation/Degradation

In cell Western

Quantification of intracellular signaling in whole cells, IKZF1/3 degradation

Migration assay

Transwell

Reporter assay

NanoBiT, NanoBRET,luciferase, GFP, β-gal, β-lac

RT-PCR

mRNA expression quantification

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Inventory of the three major in vitro pharmacokinetic research methods

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Novel Parkinson’s Therapies Possible with New Mouse Model

Parkinson's disease (PD) is a neurodegenerative disorder that is marked by the accumulation of the protein, α-synuclein (αS), into clumps known as Lewy bodies, which diminish neural health. Now, researchers from Brigham and Women's Hospital (BWH) report the development of a mouse model to induce PD-like αS aggregation, leading to resting tremor and abnormal movement control. The mouse responds to L-DOPA, similarly to patients with PD. The team's study (“Abrogating Native α-Synuclein Tetramers in Mice Causes a L-DOPA-Responsive Motor Syndrome Closely Resembling Parkinson’s Disease”) on the use of this transgenic mouse model appears in Neuron . “α-Synuclein (αS) regulates vesicle exocytosis but forms insoluble deposits in PD. Developing disease-modifying therapies requires animal models that reproduce cardinal features of PD. We recently described a previously unrecognized physiological form of αS, α-helical tetramers, and showed that familial PD-causing missense mutati

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