Six consecutive years! Medicilon once again tops the '2023 China CXO Enterprise Top 20 List'

On June 25^th, the "Resilience and Innovation: 2024 Mithink Summit" hosted by Menet, a subsidiary of the Southern Institute of Medical Economics under the National Medical Products Administration, released the 2023 China Pharmaceutical Industry Top 100 Rankings lists. Medicilon, with its outstanding R&D capabilities and continuous spirit of innovation, has once again topped the 2023 China CXO (including CDMO) Enterprise Top 20 List. This is the sixth consecutive year that Medicilon has received this honor.

Medicilon's sixth consecutive win of this honor not only represents the industry's authoritative recognition of its comprehensive biopharmaceutical preclinical R&D service platform, but also affirms its contributions to the pharmaceutical research and development field.

About the China's Top 100 Pharmaceutical Industry List Series

The "China's Top 100 Pharmaceutical Industry List Series" as an authoritative industry list, initiated and hosted by Menet.com.cn, aims to set benchmarks for china pharmaceutical enterprises to enhance comprehensive strength, expand brand influence, showcase outstanding achievements in the pharmaceutical industry, and guide stable, rapid, and sustainable development in the healthcare industry. Menet Research Institute, leveraging its exclusively developed and operated database covering three major terminals and six market segments, conducted a rigorous and scientific selection process based on two crucial dimensions for pharmaceutical industry enterprises: innovation driving force and professional promotion capability. This process ultimately determined the China's Top 100 Pharmaceutical Industry List Series.

With the rapid development of pharmaceutical technology, emerging fields such as bispecific/multispecific antibodies, ADCs, PROTACs, mRNA vaccines, small nucleic acids, and cellular and immune therapies are gradually becoming the focus of industry attention. Medicilon actively plans forward, establishing a series of efficient and cutting-edge technology service platforms, continuously driving technological innovation and iteration, and leading industry development trends. As of the end of April 2024, Medicilon has provided drug development services to over 2,000 global clients. They have been involved in the research and development of 480 new drug and generic drug projects, with IND approvals obtained from regulatory authorities such as China NMPA, the US FDA, the EU EMEA, and Australia TGA, allowing entry into clinical trials.

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What is preclinical testing?

In the process of preclinical testing of a compound or biological agent into a drug, the compound involved must go through the testing phase. First, we need to identify potential targets that can treat the disease. Then, a variety of compounds or preparations are screened out. Any compound that has shown potential as a drug for the treatment of this disease needs to be tested for toxicity before clinical testing to reduce the possibility of injury. preclinical testing What is the basis of preclinical testing? According to US Food and Drug Administration (FDA) regulations, a series of tests are required before a new drug is approved for use. In the first stage, basic research determines a hypothetical target for the treatment of a certain disease, and then screens small molecules or biological compounds to discover any substance with the potential to treat the disease. Then, a preclinical research phase followed, before which, as described above, the potential toxicity of the compou

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Inventory of the three major in vitro pharmacokinetic research methods

The metabolic properties of a compound are an essential factor in whether or not it can be used as a drug in the clinical setting, so pharmacokinetic studies of newly synthesized compounds are required in drug development. In vitro incubation with liver microsomes, recombinant CYP450 enzyme lines, and in vitro incubation with hepatocytes are some of the more common in vitro drug metabolism methods. 1. In vitro incubation method with liver microsomes The metabolic stability and metabolic phenotypes of candidate compounds in different species of liver microsomes are good predictors of the metabolic properties of compounds in vivo. They are practical tools for evaluating candidate compounds in the pre-development phase of drug development. Liver microsomes include rat liver microsomes, human liver microsomes, canine liver microsomes, monkey liver microsomes, and mouse liver microsomes. In in vitro incubation of the liver, microsomes are the "gold standard" for in vitro d

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Novel Parkinson’s Therapies Possible with New Mouse Model

Parkinson's disease (PD) is a neurodegenerative disorder that is marked by the accumulation of the protein, α-synuclein (αS), into clumps known as Lewy bodies, which diminish neural health. Now, researchers from Brigham and Women's Hospital (BWH) report the development of a mouse model to induce PD-like αS aggregation, leading to resting tremor and abnormal movement control. The mouse responds to L-DOPA, similarly to patients with PD. The team's study (“Abrogating Native α-Synuclein Tetramers in Mice Causes a L-DOPA-Responsive Motor Syndrome Closely Resembling Parkinson’s Disease”) on the use of this transgenic mouse model appears in Neuron . “α-Synuclein (αS) regulates vesicle exocytosis but forms insoluble deposits in PD. Developing disease-modifying therapies requires animal models that reproduce cardinal features of PD. We recently described a previously unrecognized physiological form of αS, α-helical tetramers, and showed that familial PD-causing missense mutati

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