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Integrated Services

Our one-stop comprehensive Integrated Service utilizes our Biology, Chemistry, and Preclinical services for the convenience of our clients. This route features the insight and expertise of our entire management team and a more economical solution to advancing your breakthroughs.
  • Hit–>IND Filing
  • Lead Optimization–>IND Filing
  • Preclinical Candidate–>IND Filing

Biology:

Protein Production
  • Protein Crystallization, Co-crystallization & Soaking
  • 3-D Structural Determination
  • Molecular Modeling & SBDD
  • Screening & Profiling
  • In Vitro Pharmacology
  • In Vitro ADMET

Chemistry

  • Medicinal Chemistry & Lead Optimization
  • Design & Synthesis of Focused Libraries 
  • Computational Chemistry & CADD
  • Custom Synthesis & Scale-up Synthesis
  • Analytical Chemistry

Preclinical

ADME: Bioanalytical Services; Preclinical PK & TK; Metabolism Services
Animal Disease Models: Cancer; Metabolic Disease; CNS Disease; Inflammation & Immunological Disease
Toxicology
Non-GLP Tox & GLP Tox
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What is preclinical testing?

In the process of  preclinical testing  of a compound or biological agent into a drug, the compound involved must go through the testing phase. First, we need to identify potential targets that can treat the disease. Then, a variety of compounds or preparations are screened out. Any compound that has shown potential as a drug for the treatment of this disease needs to be tested for toxicity before clinical testing to reduce the possibility of injury. preclinical testing What is the basis of preclinical testing? According to US Food and Drug Administration (FDA) regulations, a series of tests are required before a new drug is approved for use. In the first stage, basic research determines a hypothetical target for the treatment of a certain disease, and then screens small molecules or biological compounds to discover any substance with the potential to treat the disease. Then, a  preclinical research  phase followed, before which, as described above, the potential tox...
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Inventory of the three major in vitro pharmacokinetic research methods

  The metabolic properties of a compound are an essential factor in whether or not it can be used as a drug in the clinical setting, so pharmacokinetic studies of newly synthesized compounds are required in drug development. In vitro incubation with liver microsomes, recombinant CYP450 enzyme lines, and in vitro incubation with hepatocytes are some of the more common in vitro drug metabolism methods. 1. In vitro incubation method with liver microsomes The metabolic stability and metabolic phenotypes of candidate compounds in different species of liver microsomes are good predictors of the metabolic properties of compounds in vivo. They are practical tools for evaluating candidate compounds in the pre-development phase of drug development. Liver microsomes include rat liver microsomes, human liver microsomes, canine liver microsomes, monkey liver microsomes, and mouse liver microsomes. In in vitro incubation of the liver, microsomes are the "gold standard" for in vitro d...
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Enzyme Activity Assay Service

  Enzymatic assay Lance Assay Alphascreen Assay Z’-LYTE Assay Adapta Assay Kinase-Glo Assay ADP-Glo Assay Ligand Binding Assay ELISA Assay HTRF Assay Enzyme activity assays  are laboratory methods for measuring enzymatic activity. They are vital for the study of enzyme kinetics and enzyme inhibition. Enzyme units : Amounts of enzymes can either be expressed as molar amounts, as with any other chemical, or measured in terms of activity, in enzyme units. Medicilon provides various  enzyme activity assays  for  kinases , phosphatases, proteinases, deacetylase, peptidase, esterase, and other enzymes. Our line of well-characterized immunoassays and biochemical kits ensures accurate and reproducible results. Enzyme is a  large category of bio-molecules  that catalyze various biological processes including metabolic processes, cellular signaling and regulation, cell division and apoptosis. Enzymatic reactions convert substrate molecules into chemically modifi...
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