跳至主要内容

New non-small cell lung cancer study to explore genetics of mutation

There were an estimated 410,000 new cases of lung cancer and 353,000 deaths from lung cancer in Europe in 2012. This makes lung cancer the fourth most common cancer site (after female breast, 464,000 cases, colorectal, 447,000 cases, and prostate, 417,000 cases) but the leading cause of cancer death in Europe. It is a frequent and deadly disease.
Non-small cell lung cancer (NSCLC) is the most common type of lung cancer accounting for 85% of all lung cancer cases, and although numerous studies have documented a higher risk for developing NSCLC among smokers, non-smokers also develop lung cancer. This suggests that there are additional risk factors involved in developing this disease. It is thought that both somatic gene mutations (mutations that can occur in the cancer), as well as germline gene mutations (mutations that are inherited), contribute to NSCLC carcinogenesis.
Somatic epidermal growth factor receptor (EGFR) mutations occur more frequently in females and in East Asian patients. Therefore, the EORTC 08114-GEM intergroup translational research-observational study is designed to explore the underlying genetic factors associated with development of EGFR mutant NSCLC. The study seeks to catalogue the distribution of somatic EGFR mutant genotypes in 1,000 EGFR mutant NSCLC cases and describe their relationship to clinical outcome, identify germline DNA variants associated with somatic EGFR mutations in NSCLC, to correlate their relationship with survival, and finally to investigate germline DNA variants associated with development of NSCLC in this cohort of predominantly never/ex-light smokers.
Dr. Sanjay Popat of the Royal Marsden Hospital - Chelsea, London, and Coordinator of this trial says, “We are developing a good understanding of the molecular events that drive lung cancer. The best characterized of these is somatic EGFR mutation. Still, the genetic reasons why EGFR mutations occur in lung cancer, predominantly in never smokers, females, adenocarcinomas, and in East Asian patients are not well understood. So, this study will enroll patients with somatic EGFR mutant lung cancer, and a best "environmentally matched" control population of patients without the EGFR mutation, aiming to identify DNA variants associated with development of the EGFR mutation, and to assess their possible influence on patient survival.”
The EORTC intergroup 08114-GEM trial plans to accrue a total of 2000 patients. The Case Group will comprise 1,000 patients with EGFR mutant NSCLC, and the Control Group will comprise 1,000 patients with EGFR wild type NSCLC who either never smoked or are ex-light smokers. It will be conducted in more than 50 sites in several countries including Belgium, Egypt, Greece, Poland and the United Kingdom (UK). This trial is led by the EORTC Lung Cancer Group in collaboration with the UK National Cancer Research Institute and Professor Mark Lathrop at the Genome innovation Centre, Quebec, Canada. This is an academic trial supported by the EORTC Lung Cancer Group without any support from industry.
Find out more "www.medicilon.com"

评论

发表评论

此博客中的热门博文

What is preclinical testing?

In the process of  preclinical testing  of a compound or biological agent into a drug, the compound involved must go through the testing phase. First, we need to identify potential targets that can treat the disease. Then, a variety of compounds or preparations are screened out. Any compound that has shown potential as a drug for the treatment of this disease needs to be tested for toxicity before clinical testing to reduce the possibility of injury. preclinical testing What is the basis of preclinical testing? According to US Food and Drug Administration (FDA) regulations, a series of tests are required before a new drug is approved for use. In the first stage, basic research determines a hypothetical target for the treatment of a certain disease, and then screens small molecules or biological compounds to discover any substance with the potential to treat the disease. Then, a  preclinical research  phase followed, before which, as described above, the potential toxicity of the compou
发表评论
阅读全文

Inventory of the three major in vitro pharmacokinetic research methods

  The metabolic properties of a compound are an essential factor in whether or not it can be used as a drug in the clinical setting, so pharmacokinetic studies of newly synthesized compounds are required in drug development. In vitro incubation with liver microsomes, recombinant CYP450 enzyme lines, and in vitro incubation with hepatocytes are some of the more common in vitro drug metabolism methods. 1. In vitro incubation method with liver microsomes The metabolic stability and metabolic phenotypes of candidate compounds in different species of liver microsomes are good predictors of the metabolic properties of compounds in vivo. They are practical tools for evaluating candidate compounds in the pre-development phase of drug development. Liver microsomes include rat liver microsomes, human liver microsomes, canine liver microsomes, monkey liver microsomes, and mouse liver microsomes. In in vitro incubation of the liver, microsomes are the "gold standard" for in vitro d
发表评论
阅读全文

Novel Parkinson’s Therapies Possible with New Mouse Model

Parkinson's disease (PD) is a neurodegenerative disorder that is marked by the accumulation of the protein, α-synuclein (αS), into clumps known as Lewy bodies, which diminish neural health. Now, researchers from Brigham and Women's Hospital (BWH) report the development of a mouse model to induce PD-like αS aggregation, leading to resting tremor and abnormal movement control. The mouse responds to L-DOPA, similarly to patients with PD. The team's study (“Abrogating Native α-Synuclein Tetramers in Mice Causes a L-DOPA-Responsive Motor Syndrome Closely Resembling Parkinson’s Disease”) on the use of this transgenic mouse model appears in  Neuron . “α-Synuclein (αS) regulates vesicle exocytosis but forms insoluble deposits in PD. Developing disease-modifying therapies requires animal models that reproduce cardinal features of PD. We recently described a previously unrecognized physiological form of αS, α-helical tetramers, and showed that familial PD-causing missense mutati
发表评论
阅读全文