Enzyme Catalysis

 As a CRO that advocates green drug research and development, Medicilon has always been committed to promoting the green upgrading of pharmaceutical processes through technological innovation. Medicilon has already used enzymes in process research and development, and relying on its strong chemical and biological background, Medicilon has established a the Enzyme Catalysis Technology Platform to screen catalytic enzymes for specific reaction types and establish corresponding enzyme libraries to assist process development and production.

Medicilon Enzyme Catalysis Service Platform

• 01 Chemical Technology Platform

  Development of Pharmaceutical Intermediates and APls

  Functional Chemical Development

  02 Biotechnology Platform

  Enzyme Development and Applications

  Enzyme Production

  03 Quality Technology Platform

  Quality and Control Research

  Inspection and Testing Services

  
  Medicilon's Enzyme Catalysis Technology Platform includes chemical technology platform, biotechnology platform, and quality technology platform.  The platform focuses on the combination of chemical synthesis and biological enzyme catalytic synthesis, the development and application research of biological enzymes, and the R&D and production of pharmaceutical intermediates and APIs using green biotechnology.  At the same time, it provides high-end CRO, CDMO services, testing and quality research services to pharmaceutical companies.

Medicilon Enzyme Library

Ketoreductase	D-amino acid dehydrogenase	Transaminase	Nitrile Hydratase	Phenylalanine Lyase	Hydroaminase
Cytochrome Monooxygenase	Threonine Dehydrogenase	Phosphokinase	Epoxide Hydrolase		Nitrilase
Alcohol Oxidase	Formate Dehydrogenase	Nucleoside Phosphorylation (synthesis)	Amidohydrolase		Aldol Condensase
Monoamine Oxidase	Glucose Dehydrogenase		Nitrilase		Other Specialized Enzymes
Nitrile	Lactate			Lactate
Reductase	Dehydrogenase			Dehydrogenase
Nitroreductase	Phenylalanine Dehydrogenase
Imine Reductase	Ammonia Dehydrogenase

• At present, Medicilon has successfully established dozens of major biological enzyme libraries, such as ketoreductase, ester hydrolase, imine reductase, nitroreductase, cyclooxygenase, amide hydrolase, for providing suitable biocatalytic solutions for various chemical transformations.  These integrated enzymatic services reduce costs, shorten time, and improve quality.  With the implementation of a large amount of projects, Medicilon enzyme library is also continuing to be optimized and expanded.  Medicilon will also carry out research on immobilized enzymes and coenzymes.

Medicilon’s R&D capabilities in the field of synthetic biology

• With the continuous advancement of synthetic biology technology, more and more enzymes with specific catalytic functions are used as biocatalysts to achieve reactions that are difficult to achieve with chemical catalysts, and can be used as catalytic components to build functional modules of synthetic biology.  Medicilon has already established a presence in the field of synthetic biology. Through the assembly of different enzyme components, Medicilon has made breakthroughs in the design of synthetic routes for many target molecules and can provide a variety of services:
  Molecule and Strain ConstructionStrain Delection and DomesticationEnzyme Co-ExpressionMulti-Enzyme CatalysisBiocatalysisProtein ModificationFermentation MetabolismProtein PurificationFermentation OptimizationEnzyme Immobilization
  In the future, Medicilon, as a one-stop biopharmaceutical preclinical R&D service platform, will continue to explore and apply more innovative green chemical technologies to achieve more environmentally friendly, safe, efficient and economical process development and production, and create more innovative products for global clients.