Hybridoma Technology

Medicilon biology department has established an antibody drug development platform, and our team members have more than 10 years experience in custom antibody production. Medicilon's hybridoma R&D services can provide a variety of immunization methods (proteins, peptides, small molecules, whole cells) to meet with the client's needs.

Development Process of Hybridoma Technology Platform

Experimental Timeline

- 01
  Antigen preparation (provided by the customer or Medicilon)
- 02
  Standard immunization and serum titer testing
  6-8 weeks
- 03
  Fusion screening subclones
  4-6 weeks
- 04
  Providing antibody sequence
  2 weeks

Service Advantage

Advanced animal facilities:AAALAC certification;Multiple Immunization methods: Medicilon offers various antigen immunization schemes such as protein, peptide, VLP, whole cell and DNA for antigen preparation;High-throughput screening: FACS, ELISA workstation, Biacore affinity, etc., with high screening efficiency;Comprehensive functional testing services:The functional verification testing platform provides in-vitro pharmacodynamic testing services such as Affinity Ranking, Affinity Measurement, EC50 and IC50, and Cross-reactivity; etc.

Advanced Equipment

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What is preclinical testing?

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Inventory of the three major in vitro pharmacokinetic research methods

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Novel Parkinson’s Therapies Possible with New Mouse Model

Parkinson's disease (PD) is a neurodegenerative disorder that is marked by the accumulation of the protein, α-synuclein (αS), into clumps known as Lewy bodies, which diminish neural health. Now, researchers from Brigham and Women's Hospital (BWH) report the development of a mouse model to induce PD-like αS aggregation, leading to resting tremor and abnormal movement control. The mouse responds to L-DOPA, similarly to patients with PD. The team's study (“Abrogating Native α-Synuclein Tetramers in Mice Causes a L-DOPA-Responsive Motor Syndrome Closely Resembling Parkinson’s Disease”) on the use of this transgenic mouse model appears in Neuron . “α-Synuclein (αS) regulates vesicle exocytosis but forms insoluble deposits in PD. Developing disease-modifying therapies requires animal models that reproduce cardinal features of PD. We recently described a previously unrecognized physiological form of αS, α-helical tetramers, and showed that familial PD-causing missense mutati

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