Hybridoma Technology

Medicilon biology department has established an antibody drug development platform, and our team members have more than 10 years experience in custom antibody production. Medicilon's hybridoma R&D services can provide a variety of immunization methods (proteins, peptides, small molecules, whole cells) to meet with the client's needs.

Development Process of Hybridoma Technology Platform

Experimental Timeline

- 01
  Antigen preparation (provided by the customer or Medicilon)
- 02
  Standard immunization and serum titer testing
  6-8 weeks
- 03
  Fusion screening subclones
  4-6 weeks
- 04
  Providing antibody sequence
  2 weeks

Service Advantage

Advanced animal facilities:AAALAC certification;Multiple Immunization methods: Medicilon offers various antigen immunization schemes such as protein, peptide, VLP, whole cell and DNA for antigen preparation;High-throughput screening: FACS, ELISA workstation, Biacore affinity, etc., with high screening efficiency;Comprehensive functional testing services:The functional verification testing platform provides in-vitro pharmacodynamic testing services such as Affinity Ranking, Affinity Measurement, EC50 and IC50, and Cross-reactivity; etc.

Advanced Equipment

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Custom Synthesis

Medicilon has synthesized over 10,000 individual compounds from gram to kilogram quantities, and many compounds are synthesized with more than ten synthetic steps. The overall synthesis success rate is over 95%. High quality products from mg to kg scale Reagents, intermediates, building blocks, and scaffolds Preparation of API or reference standards Development of synthetic routes for impurities and metabolites On-site analytical support Product delivered with COA Medicilon offers integrated drug discovery services -- Chemistry, Biology & Preclinical Services

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In Vitro Enzyme Activity Assay

Kinases play extensive and important roles in signal transduction and co-ordination of complex functions. Currently, about 300 kinase inhibitors have been approved for marketing, among which receptor tyrosine kinase (RTK) inhibitors are the main ones. Medicilon provides high-quality kinase profile screening and has one-stop kinase research services from assay development, high-throughput screening to selectivity analysis. In addition, Medicilon provides many other enzyme activity screens. Wide Variety Provides 200+ in vitro enzymatic detection methods; 100+ kinases, including CTK, RTK, AGC, CMGC and other kinase families as well as important common mutations Project Flexibility Various types of plates for screening, such as 96 and 384; Multiple flexible kinase profiles, including TK kinase family, CDK kinase family, etc., to meet different customer customization needs. Various Methods Fluorescence detection; Chemiluminescence detection; Absorbance detection LanthaScr...

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Pharmacokinetics Services

Pharmacokinetics Services Our pharmacokinetics department offers the clients a broad spectrum of high quality of services in the areas of in vitro ADME, in vivo pharmacokinetics and bioanalysis services, ranging from small molecules to large molecules, such as protein and antibody. The animal species involved in our services are non-human primate, canine, mice, rat, rabbit and hamster. Meanwhile, non-human primate experimental platform and isotope platform for protein/antibody are certified by the Shanghai government. Preclinical Pharmacokinetics Method development and validation (GLP,Non-GLP) Bioanalysis Pharmacokinetics (Tumor bearing rodents, Bioavailability, Crossover studies, Cassette (N in 1) dosing and analysis, effects of gender on pharmacokinetics, BBB penetration ) Stability in vehicles and plasma Drug interaction studies In vitro metabolic stability CYP 450 inhibition Plasma protein binding studies Distribution studies Excretion studies Prediction an...

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Shanghai Medicilon Inc.

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