GLP Toxicology Studies

To assess toxicity, Medicilon offers a wide range of GLP and non-GLP toxicology services. GLP and non-GLP Toxicology studies are required to determine the adverse effects of drug candidates and the effect of dosage on toxicity.

glp toxicology study

Preclinical CRO / Toxicology Studies Include:

Late-Stage Discovery Studies

Pharmacokinetics Study (PK)
Maximum Tolerated Dose Studies (MTD)
Dose Range Finding Study
hERG - Ion Channel Screening
Exploratory Toxicology Study (7-day non-GLP Studies with PK)

GLP Toxicology Studies

7-day Repeat Dose Study (GLP)
14-day Repeat Dose Study (GLP)
21-day Repeat Dose Study (GLP)
3-month Chronic Repeat Dose Study (GLP)
6-month Chronic Repeat Dose Study (GLP)
9-month Chronic Repeat Dose Study (GLP)
Carcinogenicity Studies (Transgenic & 2 year)

Safety Pharmacology Studies (GLP)

Cardiovascular Study (Telemetry or Piggy-backed)
Respiratory Study
Central Nervous System Study (CNS Study)

Genetic Toxicology (Genetox)

Ames Assay (non-GLP & GLP) CRO
Micronucleus Assay
Chromosomal Aberration Assay

With extensive experience in drug development, Medicilon staff is dedicated to helping you complete your project in a timely and efficient manner. In addition to Good Laboratory Practice (GLP) toxicology studies, Medicilon provides all aspects of the GLP process from design to regulatory support of your IND FDA submission. Our preclinical team has extensive experience in set-up and management of GLP animal toxicology studies and other experience across all facets of preclinical research, from identification, assessment and due diligence on new compounds to conduct of animal models.

Contact Us

Email : marketing@medicilon.com

Tel : +86 021 5859-1500

Tips : Above is part of GLP Toxicology Studies, GLP Toxicology and Toxicology Testing Labs. You can also CONTACT US with any question or enquiry you may have. We will be happy to discuss your needs in detail and design an appropriate plan of action.

New Drug Preclinical Toxicology Research

General Toxicology Study Service

Drug Safety Evaluation Center

Pharmacokinetic test / toxicokinetic test

Medicilon attended the 6th National Congress of Toxicology successfully in Guangzhou

Preclinical studies and clinical trials of drugs

Toxicokinetic Studies in Animals

此博客中的热门博文

What is preclinical testing?

In the process of preclinical testing of a compound or biological agent into a drug, the compound involved must go through the testing phase. First, we need to identify potential targets that can treat the disease. Then, a variety of compounds or preparations are screened out. Any compound that has shown potential as a drug for the treatment of this disease needs to be tested for toxicity before clinical testing to reduce the possibility of injury. preclinical testing What is the basis of preclinical testing? According to US Food and Drug Administration (FDA) regulations, a series of tests are required before a new drug is approved for use. In the first stage, basic research determines a hypothetical target for the treatment of a certain disease, and then screens small molecules or biological compounds to discover any substance with the potential to treat the disease. Then, a preclinical research phase followed, before which, as described above, the potential toxicity of the compou

阅读全文

Inventory of the three major in vitro pharmacokinetic research methods

The metabolic properties of a compound are an essential factor in whether or not it can be used as a drug in the clinical setting, so pharmacokinetic studies of newly synthesized compounds are required in drug development. In vitro incubation with liver microsomes, recombinant CYP450 enzyme lines, and in vitro incubation with hepatocytes are some of the more common in vitro drug metabolism methods. 1. In vitro incubation method with liver microsomes The metabolic stability and metabolic phenotypes of candidate compounds in different species of liver microsomes are good predictors of the metabolic properties of compounds in vivo. They are practical tools for evaluating candidate compounds in the pre-development phase of drug development. Liver microsomes include rat liver microsomes, human liver microsomes, canine liver microsomes, monkey liver microsomes, and mouse liver microsomes. In in vitro incubation of the liver, microsomes are the "gold standard" for in vitro d

阅读全文

Enzyme Activity Assay Service

Enzymatic assay Lance Assay Alphascreen Assay Z’-LYTE Assay Adapta Assay Kinase-Glo Assay ADP-Glo Assay Ligand Binding Assay ELISA Assay HTRF Assay Enzyme activity assays are laboratory methods for measuring enzymatic activity. They are vital for the study of enzyme kinetics and enzyme inhibition. Enzyme units : Amounts of enzymes can either be expressed as molar amounts, as with any other chemical, or measured in terms of activity, in enzyme units. Medicilon provides various enzyme activity assays for kinases , phosphatases, proteinases, deacetylase, peptidase, esterase, and other enzymes. Our line of well-characterized immunoassays and biochemical kits ensures accurate and reproducible results. Enzyme is a large category of bio-molecules that catalyze various biological processes including metabolic processes, cellular signaling and regulation, cell division and apoptosis. Enzymatic reactions convert substrate molecules into chemically modified molecules products with high sp

阅读全文

Shanghai Medicilon Inc.

搜索此博客