Ion Channel Screening Services

Medicilon provides a wide range of ion channel assays to quickly and accurately provide results for drug discovery and development research worldwide. We offer ion channel screening services on a variety of different high quality electrophysiology platforms. These services include:

Compound Screening
Our screening compound system allows chemists and compound managers to quickly and easily purchase screening compounds for your HTS library.

Cell Line Optimization
Medicilon’s scientists have extensive experience of developing, optimizing and validating stable cell lines expressing recombinant and endogenous ion channels.

Assay Development
Medicilon’s scientists have over a decade of hands-on experience building and optimizing automated and manual patch clamp assays for a wide range of ion channel targets. Our scientists are able to fully customize ion channel assays at different stages of the screening cascade, from medium throughput SAR or hit finding through to specialized biophysical and mechanism-of-action studies for hit series or lead compounds.

Ion Channel Library
We offer validated ion channel screening services against the ion channels in our library and for several other target class panels available from commercial vendors. We are always seeking to expand our library of ion channel cell lines, so please contact us to determine if we can assist you with an ion channel of interest.

Our team provides the following services:

Target Assessment – Drug Targets
HITs Identification
Lead Optimization
Clinical Candidate Nomination
Computer Aided Drug Design
SAR Study

With our extensive experience in medicinal chemistry, we are able to promote drug discovery programs into development and clinical trial stage efficiently and cost-effectively.

Our advantages:

Fully Customized Service
Multiple Testing Panels
Various Detection Methods
Time & Cost-Efficient
Best Price In The Market

Contact Us

Email : marketing@medicilon.com

Tel : +86 021 58591500

Tips : Above is part of ion channel assays,ion channel screening service. You can also CONTACT US with any question or enquiry you may have. We will be happy to discuss your needs in detail and design an appropriate plan of action.

Medicilon ion channel screening service

此博客中的热门博文

What is preclinical testing?

In the process of preclinical testing of a compound or biological agent into a drug, the compound involved must go through the testing phase. First, we need to identify potential targets that can treat the disease. Then, a variety of compounds or preparations are screened out. Any compound that has shown potential as a drug for the treatment of this disease needs to be tested for toxicity before clinical testing to reduce the possibility of injury. preclinical testing What is the basis of preclinical testing? According to US Food and Drug Administration (FDA) regulations, a series of tests are required before a new drug is approved for use. In the first stage, basic research determines a hypothetical target for the treatment of a certain disease, and then screens small molecules or biological compounds to discover any substance with the potential to treat the disease. Then, a preclinical research phase followed, before which, as described above, the potential toxicity of the compou

阅读全文

Inventory of the three major in vitro pharmacokinetic research methods

The metabolic properties of a compound are an essential factor in whether or not it can be used as a drug in the clinical setting, so pharmacokinetic studies of newly synthesized compounds are required in drug development. In vitro incubation with liver microsomes, recombinant CYP450 enzyme lines, and in vitro incubation with hepatocytes are some of the more common in vitro drug metabolism methods. 1. In vitro incubation method with liver microsomes The metabolic stability and metabolic phenotypes of candidate compounds in different species of liver microsomes are good predictors of the metabolic properties of compounds in vivo. They are practical tools for evaluating candidate compounds in the pre-development phase of drug development. Liver microsomes include rat liver microsomes, human liver microsomes, canine liver microsomes, monkey liver microsomes, and mouse liver microsomes. In in vitro incubation of the liver, microsomes are the "gold standard" for in vitro d

阅读全文

Novel Parkinson’s Therapies Possible with New Mouse Model

Parkinson's disease (PD) is a neurodegenerative disorder that is marked by the accumulation of the protein, α-synuclein (αS), into clumps known as Lewy bodies, which diminish neural health. Now, researchers from Brigham and Women's Hospital (BWH) report the development of a mouse model to induce PD-like αS aggregation, leading to resting tremor and abnormal movement control. The mouse responds to L-DOPA, similarly to patients with PD. The team's study (“Abrogating Native α-Synuclein Tetramers in Mice Causes a L-DOPA-Responsive Motor Syndrome Closely Resembling Parkinson’s Disease”) on the use of this transgenic mouse model appears in Neuron . “α-Synuclein (αS) regulates vesicle exocytosis but forms insoluble deposits in PD. Developing disease-modifying therapies requires animal models that reproduce cardinal features of PD. We recently described a previously unrecognized physiological form of αS, α-helical tetramers, and showed that familial PD-causing missense mutati

阅读全文

Shanghai Medicilon Inc.

搜索此博客