跳至主要内容

Ion Channel Screening Services

 


Medicilon provides a wide range of ion channel assays to quickly and accurately provide results for drug discovery and development research worldwide. We offer ion channel screening services on a variety of different high quality electrophysiology platforms. These services include:

Compound Screening 
Our screening compound system allows chemists and compound managers to quickly and easily purchase screening compounds for your HTS library.

Cell Line Optimization
Medicilon’s scientists have extensive experience of developing, optimizing and validating stable cell lines expressing recombinant and endogenous ion channels.

Assay Development
Medicilon’s scientists have over a decade of hands-on experience building and optimizing automated and manual patch clamp assays for a wide range of ion channel targets. Our scientists are able to fully customize ion channel assays at different stages of the screening cascade, from medium throughput SAR or hit finding through to specialized biophysical and mechanism-of-action studies for hit series or lead compounds.

Ion Channel Library
We offer validated ion channel screening services against the ion channels in our library and for several other target class panels available from commercial vendors. We are always seeking to expand our library of ion channel cell lines, so please contact us to determine if we can assist you with an ion channel of interest.

Our team provides the following services:

Target Assessment – Drug Targets
HITs Identification
Lead Optimization
Clinical Candidate Nomination
Computer Aided Drug Design
SAR Study

With our extensive experience in medicinal chemistry, we are able to promote drug discovery programs into development and clinical trial stage efficiently and cost-effectively.

Our advantages:

Fully Customized Service
Multiple Testing Panels
Various Detection Methods
Time & Cost-Efficient
Best Price In The Market

Contact Us

Email : marketing@medicilon.com

Tel : +86 021 58591500

 

Tips : Above is part of ion channel assays,ion channel screening service. You can also CONTACT US with any question or enquiry you may have. We will be happy to discuss your needs in detail and design an appropriate plan of action.

 

Related Articles:

Medicilon ion channel screening service

评论

此博客中的热门博文

What is preclinical testing?

In the process of  preclinical testing  of a compound or biological agent into a drug, the compound involved must go through the testing phase. First, we need to identify potential targets that can treat the disease. Then, a variety of compounds or preparations are screened out. Any compound that has shown potential as a drug for the treatment of this disease needs to be tested for toxicity before clinical testing to reduce the possibility of injury. preclinical testing What is the basis of preclinical testing? According to US Food and Drug Administration (FDA) regulations, a series of tests are required before a new drug is approved for use. In the first stage, basic research determines a hypothetical target for the treatment of a certain disease, and then screens small molecules or biological compounds to discover any substance with the potential to treat the disease. Then, a  preclinical research  phase followed, before which, as described above, the potential tox...

Inventory of the three major in vitro pharmacokinetic research methods

  The metabolic properties of a compound are an essential factor in whether or not it can be used as a drug in the clinical setting, so pharmacokinetic studies of newly synthesized compounds are required in drug development. In vitro incubation with liver microsomes, recombinant CYP450 enzyme lines, and in vitro incubation with hepatocytes are some of the more common in vitro drug metabolism methods. 1. In vitro incubation method with liver microsomes The metabolic stability and metabolic phenotypes of candidate compounds in different species of liver microsomes are good predictors of the metabolic properties of compounds in vivo. They are practical tools for evaluating candidate compounds in the pre-development phase of drug development. Liver microsomes include rat liver microsomes, human liver microsomes, canine liver microsomes, monkey liver microsomes, and mouse liver microsomes. In in vitro incubation of the liver, microsomes are the "gold standard" for in vitro d...

Enzyme Activity Assay Service

  Enzymatic assay Lance Assay Alphascreen Assay Z’-LYTE Assay Adapta Assay Kinase-Glo Assay ADP-Glo Assay Ligand Binding Assay ELISA Assay HTRF Assay Enzyme activity assays  are laboratory methods for measuring enzymatic activity. They are vital for the study of enzyme kinetics and enzyme inhibition. Enzyme units : Amounts of enzymes can either be expressed as molar amounts, as with any other chemical, or measured in terms of activity, in enzyme units. Medicilon provides various  enzyme activity assays  for  kinases , phosphatases, proteinases, deacetylase, peptidase, esterase, and other enzymes. Our line of well-characterized immunoassays and biochemical kits ensures accurate and reproducible results. Enzyme is a  large category of bio-molecules  that catalyze various biological processes including metabolic processes, cellular signaling and regulation, cell division and apoptosis. Enzymatic reactions convert substrate molecules into chemically modifi...