Gain Client Recognition Again! Medicilon won the 2023 SicaGene "Best Partner Award"

Recently, Shanghai Medicilon Inc. (Medicilon) won the "Best Partner Award" from SicaGene. The strong support provided in collaboration projects has been recognized by client again.

Medicilon and SicaGene: Go Deep Alone, Go Far Together

The collaboration stems from a shared vision in the field of nucleic acid drugs. Antisense oligonucleotide drugs can break through the "undruggable targets" limitations of traditional small molecule drugs, but they also have extremely high technical barriers and development difficulties. As one of the first China innovative pharmaceutical companies to enter the ASO field, SicaGene has independently developed and constructed core technology platforms such as SicaScreenTM、SicaChemistryTM、SicaDeliveryTM , focusing on drug development in the fields of cardiovascular disease, viruses, and ophthalmology. SicaGene has also achieved efficient development of ASO drugs with high activity, low dosage, long administration cycle, good clinical tolerance and controllable cost.

It is also Medicilon's vision to improve the druggability and R&D efficiency of nucleic acid drugs and help nucleic acid drugs benefit the world. To this end, Medicilon relies on the Nucleic Acid Drug R&D Service Platform to empower SicaGene's ASO drug research and development, and the trust and support from SicaGene also encourage Medicilon to continue to innovate and improve. Through close collaboration between the two parties, the collaboration has achieved positive progress and phased results.

Nucleic Acid Drug R&D Service Platform provides one-stop support for R&D

Medicilon's Nucleic Acid Drug R&D Service Platform is an integrated and comprehensive platform that integrates drug discovery, production and preclinical research. Based on a rigorous scientific attitude, an open technology platform and advanced instruments and equipment, Medicilon can provide nucleic acid drug discovery, screening and preclinical research services to pharmaceutical companies and scientific research institutions.

Medicilon will continue to target cutting-edge tracks such as nucleic acid, cell and gene therapy, PROTAC, and ADC, strengthen technological innovation, and gather superior resources to provide clients with a one-stop biopharmaceutical preclinical R&D service platform and to empower global partners to accelerate pharmaceutical innovation.

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Medicilon and Binhui Biopharmaceutical Have Reached a Strategic Collaboration to Jointly Draw a New Blueprint for the Development of New Biological Drugs

On March 18, Medicilon and Binhui Biopharmaceutical (Binui Bio) announced a strategic collaboration. The two parties will work together to jointly explore the possibilities in cutting-edge fields such as oncolytic viruses, nucleic acid drugs and protein drugs. Gather and Work Together to Create Advantages Facilitate the Research and Development of Oncolytic Viruses, Nucleic Acids, Proteins and Other Drugs As a one-stop biopharmaceutical comprehensive preclinical R&D service CRO, Medicilon has been developing and accumulating for 20 years, always adhering to the spirit of innovation, and has successfully constructed bi/multi-specific antibodies, ADCs , mRNA vaccines , small nucleic acid drugs , PROTAC , and CGT technical service platform that have helped 421 INDs obtain clinical approval. It is this outstanding achievement that has earned Medicilon wide recognition in the industry and laid a solid foundation f...

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The Launch Meeting was Held by Medicilon and DAC Biotech of the Contract Research on ADC Preclinical Study

Chuansha, Shanghai, Nov. 8th, 2019 — Medicilon held the launch meeting with Hangzhou DAC Biotech Co., Ltd to initiate the preclinical study of the antibody-drug-conjugate (ADC) DXC005, including the pharmacology study , DMPK study and the safety evaluation . Medicilon has previously completed integrated preclinical research on ADC drugs cooperating with DAC Biotech and other companies. Two of them has been approved by NMPA and entered Phase I clinical trials. About Hangzhou DAC Biotech Co., Ltd Hangzhou DAC Biotech, Co., Ltd was officially registered in HEDA Area, Hangzhou City, Zhejiang Province, China around the end of Year 2012, and is located nearby the bank of beautiful Qiantang River. The company focuses on developing conjugate of monoclonal antibody and small molecular cytotoxic drug, both of which are banded together with smart linkers. About Antibody-Drug-Conjugate (ADC) ADCs ...

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A Nickel-Catalyzed Reductive Alkylation of Aryl Bromides and Chlorides for Sp3-Sp2 Bond Formation

In 2012, a nickel-catalyzed reductive alkylation method of aryl bromides and chlorides was reported. Under the optimized conditions, a variety of aryl and vinyl bromides as well as active aryl chloride can be reductively coupled with alkyl bromides in high yields. The protocols were highly functional-group tolerant and the reactions were not air or moisture sensitive. The reaction showed different chemoselectivity than conventional cross-coupling reactions. Substrates bearing both anelectrophilic and nucleophilic carbon resulted in selective coupling at the electrophilic carbon (R-X) and no reaction occurred at the nucleophilic carbon (R-[M]). The 2010 Nobel Prize in Chemistry was awarded for the Pd-catalyzed cross-coupling, and in the past decade the progress in cross-coupling has not only had a significant impact on academic research but has also influenced the industrial synthetic application. The transition-metal-catalyzed union of nucleophilic organo-boronic acids with elect...

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