Three years in a row! Medicilon once again appears on the 2023 "Influential Preclinical CRO Enterprises of the Year" list

On December 15, the 4th China Biopharmaceutical Industry Chain Innovation and Transformation Summit and the 4th China Biopharmaceutical Innovation Billboard Awards Ceremony were grandly held in Hangzhou.

This is the third consecutive year that Medicilon has won this award!

Medicilon once again appears on the 2023

As an important force in promoting and participating in the development of the biopharmaceutical industry, it is particularly meaningful for Medicilon to win this honor again on the occasion of its 20^th anniversary. This heavy honor is a tribute to Medicilon’s continuous efforts and pioneering efforts in the field of biomedical preclinical R&D in the past 20 years. It is also recognition of Medicilon's active exploration of cutting-edge fields such as nucleic acid drugs, cellular immunity, mRNA, PROTAC, ADC, bi/multi-specific antibodies and the establishment of innovative service platforms. It also fully affirms Medicilon’s one-stop biopharmaceutical preclinical R&D service platform for successfully accelerating the clinical approval of 385 INDs. At the same time, this honor also inspires Medicilon to overcome difficulties and make new achievements.

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What is preclinical testing?

In the process of preclinical testing of a compound or biological agent into a drug, the compound involved must go through the testing phase. First, we need to identify potential targets that can treat the disease. Then, a variety of compounds or preparations are screened out. Any compound that has shown potential as a drug for the treatment of this disease needs to be tested for toxicity before clinical testing to reduce the possibility of injury. preclinical testing What is the basis of preclinical testing? According to US Food and Drug Administration (FDA) regulations, a series of tests are required before a new drug is approved for use. In the first stage, basic research determines a hypothetical target for the treatment of a certain disease, and then screens small molecules or biological compounds to discover any substance with the potential to treat the disease. Then, a preclinical research phase followed, before which, as described above, the potential toxicity of the compou

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Inventory of the three major in vitro pharmacokinetic research methods

The metabolic properties of a compound are an essential factor in whether or not it can be used as a drug in the clinical setting, so pharmacokinetic studies of newly synthesized compounds are required in drug development. In vitro incubation with liver microsomes, recombinant CYP450 enzyme lines, and in vitro incubation with hepatocytes are some of the more common in vitro drug metabolism methods. 1. In vitro incubation method with liver microsomes The metabolic stability and metabolic phenotypes of candidate compounds in different species of liver microsomes are good predictors of the metabolic properties of compounds in vivo. They are practical tools for evaluating candidate compounds in the pre-development phase of drug development. Liver microsomes include rat liver microsomes, human liver microsomes, canine liver microsomes, monkey liver microsomes, and mouse liver microsomes. In in vitro incubation of the liver, microsomes are the "gold standard" for in vitro d

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Novel Parkinson’s Therapies Possible with New Mouse Model

Parkinson's disease (PD) is a neurodegenerative disorder that is marked by the accumulation of the protein, α-synuclein (αS), into clumps known as Lewy bodies, which diminish neural health. Now, researchers from Brigham and Women's Hospital (BWH) report the development of a mouse model to induce PD-like αS aggregation, leading to resting tremor and abnormal movement control. The mouse responds to L-DOPA, similarly to patients with PD. The team's study (“Abrogating Native α-Synuclein Tetramers in Mice Causes a L-DOPA-Responsive Motor Syndrome Closely Resembling Parkinson’s Disease”) on the use of this transgenic mouse model appears in Neuron . “α-Synuclein (αS) regulates vesicle exocytosis but forms insoluble deposits in PD. Developing disease-modifying therapies requires animal models that reproduce cardinal features of PD. We recently described a previously unrecognized physiological form of αS, α-helical tetramers, and showed that familial PD-causing missense mutati

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