Three years in a row! Medicilon once again appears on the 2023 "Influential Preclinical CRO Enterprises of the Year" list

On December 15, the 4th China Biopharmaceutical Industry Chain Innovation and Transformation Summit and the 4th China Biopharmaceutical Innovation Billboard Awards Ceremony were grandly held in Hangzhou.

This is the third consecutive year that Medicilon has won this award!

Medicilon once again appears on the 2023

As an important force in promoting and participating in the development of the biopharmaceutical industry, it is particularly meaningful for Medicilon to win this honor again on the occasion of its 20^th anniversary. This heavy honor is a tribute to Medicilon’s continuous efforts and pioneering efforts in the field of biomedical preclinical R&D in the past 20 years. It is also recognition of Medicilon's active exploration of cutting-edge fields such as nucleic acid drugs, cellular immunity, mRNA, PROTAC, ADC, bi/multi-specific antibodies and the establishment of innovative service platforms. It also fully affirms Medicilon’s one-stop biopharmaceutical preclinical R&D service platform for successfully accelerating the clinical approval of 385 INDs. At the same time, this honor also inspires Medicilon to overcome difficulties and make new achievements.

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Medicilon and Binhui Biopharmaceutical Have Reached a Strategic Collaboration to Jointly Draw a New Blueprint for the Development of New Biological Drugs

On March 18, Medicilon and Binhui Biopharmaceutical (Binui Bio) announced a strategic collaboration. The two parties will work together to jointly explore the possibilities in cutting-edge fields such as oncolytic viruses, nucleic acid drugs and protein drugs. Gather and Work Together to Create Advantages Facilitate the Research and Development of Oncolytic Viruses, Nucleic Acids, Proteins and Other Drugs As a one-stop biopharmaceutical comprehensive preclinical R&D service CRO, Medicilon has been developing and accumulating for 20 years, always adhering to the spirit of innovation, and has successfully constructed bi/multi-specific antibodies, ADCs , mRNA vaccines , small nucleic acid drugs , PROTAC , and CGT technical service platform that have helped 421 INDs obtain clinical approval. It is this outstanding achievement that has earned Medicilon wide recognition in the industry and laid a solid foundation f...

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A Nickel-Catalyzed Reductive Alkylation of Aryl Bromides and Chlorides for Sp3-Sp2 Bond Formation

In 2012, a nickel-catalyzed reductive alkylation method of aryl bromides and chlorides was reported. Under the optimized conditions, a variety of aryl and vinyl bromides as well as active aryl chloride can be reductively coupled with alkyl bromides in high yields. The protocols were highly functional-group tolerant and the reactions were not air or moisture sensitive. The reaction showed different chemoselectivity than conventional cross-coupling reactions. Substrates bearing both anelectrophilic and nucleophilic carbon resulted in selective coupling at the electrophilic carbon (R-X) and no reaction occurred at the nucleophilic carbon (R-[M]). The 2010 Nobel Prize in Chemistry was awarded for the Pd-catalyzed cross-coupling, and in the past decade the progress in cross-coupling has not only had a significant impact on academic research but has also influenced the industrial synthetic application. The transition-metal-catalyzed union of nucleophilic organo-boronic acids with elect...

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