Shanghai Medicilon Inc.

  Inflammation has always been a double-edged sword, providing critical action that helps heal wounds or thwart infections, in addition to damaging healthy cells and tissues due to a disproportionate response. Understanding the regulatory mechanisms that control the balance between positive and negative inflammation could open new   drug discovery   avenues for a variety of diseases and disease complications, such as sepsis.          ❖      Medicilon's Inflammatory & Immune Diseases Models At present, as the pathogenesis of inflammatory and immunological diseases is unclear, there are few effective therapeutic drugs available in clinical practice. In such a context, the appropriate preclinical research techniques and models are required to help companies and researchers further develop and evaluate new drugs. Our Preclinical Pharmacodynamics Department has been deeply involved in this field for years, developing reliable animal-based efficacy evaluation models aimed at differen

  U.K. scientists have shown how induced neural stem cells (iNSCs) derived from skin cells can reduce chronic neuroinflammation in the brains of a mouse model of multiple sclerosis (MS), and could potentially be used to hold back or repair damage to nerve cells and myelin. The University of Cambridge team, co-led by Stefano Pluchino, Ph.D., in the department of clinical neuroscience, demonstrated that injecting either embryo-derived neural stem cells (NSCs) or iNSCs directly into the animals’ cerebrospinal fluid (CSF) led to reduced CSF levels of succinate, which triggered inflammatory macrophages and microglia to switch back into an anti-inflammatory phenotype. “Our mouse study suggests that using a patient’s reprogrammed cells could provide a route to personalized treatment of chronic inflammatory diseases, including progressive forms of MS,” says Dr. Pluchino, lead author of the study. The interdisciplinary research team, including co-led by Christian Frezza, Ph.D., at the Universit

  The link between mitochondria and inflammation is still unclear. But it is known is that the accumulation of defective mitochondria that should have been removed causes inflammation.   Scientists at the Institute for Research in Biomedicine (IRB), in Barcelona, report that the removal of a single mitochondrial protein in mouse muscle leads to severe inflammation throughout the body, causing the premature death of the animal. Their study (“Mitochondrial DNA and TLR9 drive muscle inflammation upon Opa1 deficiency”) appears in  The EMBO Journal .          ❖      Medicilon's Inflammatory & Immune Diseases Models At present, as the pathogenesis of inflammatory and immunological diseases is unclear, there are few effective therapeutic drugs available in clinical practice. In such a context, the appropriate preclinical research techniques and models are required to help companies and researchers further develop and evaluate new drugs. Our Preclinical Pharmacodynamics Department has

  Researchers at the University of California San Diego (UCSD), School of Medicine discovered that they can block   inflammation   in mice with a naturally occurring antibody that binds oxidized phospholipids (OxPL), molecules on cell surfaces that get modified by inflammation. Even while on a high-fat diet, the antibody protected the mice from arterial plaque formation, hardening of the arteries, and liver disease, and prolonged their lives. The study (“Oxidized Phospholipids Are Proinflammatory and Proatherogenic in Hypercholesterolaemic Mice”) published in  Nature , marks the first demonstration in a living system that OxPL triggers inflammation and leads to plaque formation, according to the researchers, who add that the results also suggest a new approach for preventing or reversing a number of inflammatory diseases.          ❖      Medicilon's Inflammatory & Immune Diseases Models At present, as the pathogenesis of inflammatory and immunological diseases is unclear, there

  What are proteins and their importance? Protein is the material basis of life, an organic macromolecule, the basic organic matter that constitutes a cell, and the main bearer of life activities. Without protein, there would be no life. Amino acid is the basic building block of protein. The Basic Unit of Protein Structure - Amino Acid There are more than 300 kinds of amino acids in nature, and protein sequences are composed of twenty different amino acid residues. Proteins are multimers formed by linking different amino acids, and through correct folding into a specific configuration, they exert the biological function of protein drugs. Protein structure refers to the spatial structure of protein molecules. Proteins are mainly composed of chemical elements such as carbon, hydrogen, oxygen, and nitrogen. All proteins are polymers formed by connecting 20 different amino acids. After forming proteins, these amino acids are also called residues. The characteristics and functions o

Introduction of International Discovery Service Unit (IDSU) In 2021, Medicilon established the International Discovery Service Unit (IDSU) to provide global pharmaceutical companies with high quality, high efficient and cost-effective chemistry synthesis design and production, medicinal chemistry, and the discovery and project delivery of clinical candidate compounds, which empowering global drug research and development.  

  A new study finds that children with B-cell precursor acute lymphoblastic leukemia (ALL) have an immune profile at birth that differs from matched controls. Although the cause of ALL remains unknown, this finding lends support to the hypothesis that a dysregulated immune function in combination with certain postnatal environmental exposures leads to the development of the disease.   A team at the Statens Serum Institut and University Hospital Rigshospitalet in Copenhagen, Denmark published a paper titled “Neonatal Inflammatory Markers Are Associated with Childhood B-cell Precursor Acute Lymphoblastic Leukemia” in  Cancer Research  that supports this hypothesis.     The researchers, led by Henrik Hjalgrim M.D., Ph.D., consultant, department of epidemiology research at Statens Serum Institut, used data from Denmark’s Neonatal Screening Biobank and nationwide registers to conduct a population-based case-control study. They measured the concentrations of inflammatory markers, including c

  Flies eating a Spartan diet are protected from leaky gut and the systemic inflammation associated with it as they age. Conversely, flies on a rich Atkins-like diet are more prone to developing intestinal permeability, a condition linked to a variety of human conditions including inflammatory bowel disease.          ❖      Medicilon's Inflammatory & Immune Diseases Models At present, as the pathogenesis of inflammatory and immunological diseases is unclear, there are few effective therapeutic drugs available in clinical practice. In such a context, the appropriate preclinical research techniques and models are required to help companies and researchers further develop and evaluate new drugs. Our Preclinical Pharmacodynamics Department has been deeply involved in this field for years, developing reliable animal-based efficacy evaluation models aimed at different targets and pathways, thus facilitating the clinical transformation of new drugs. Publishing in  PLOS Genetics  throu

  Inflammatory immune diseases  have gained much attention as the incidence has grown bigger each year. The diseases can affect many parts of human bodies and reduce the quality of life drastically. Yet the diagnoses can be frustrating and stressful because no one is sure what causes such diseases. The  preclinical pharmacology department  of Medicilon has been deeply involved in this field for many years, and has provided a variety of stable and reliable  animal models  for different targets and pathways for the evaluation of inflammatory immune disease treatments in order for the successful clinical transformation.          ❖      Medicilon's Inflammatory & Immune Diseases Models At present, as the pathogenesis of inflammatory and immunological diseases is unclear, there are few effective therapeutic drugs available in clinical practice. In such a context, the appropriate preclinical research techniques and models are required to help companies and researchers further develop