跳至主要内容

Medicilon Tumor Animal Model Debut

 SAPA-DC 2017 Annual Scientific Seminar came to an end in Rockville, Maryland, USA on April 1, 2017.

During the meeting, Dr. Wang Jun, VP of Medicilon’s biology department, gave his speech on the “Animal Models in Drug Discovery on Immunotherapy at Medicilon”. He shared the latest developments of tumor animal model and part of technical data of Medicilon.

The conference gathered in the field of scientific research, clinical practice of medicine and policy supervision and other fields of experts and scholars on the scene of the most cutting-edge cancer immunotherapy.  The 200 experts and scholars travelled from Maryland, Pennsylvania, New Jersey and China’s domestic pharmaceutical industry.

As an important business partner of the seminar, Dr. Wang Jun said, “It is a great honor to be able to introduce Medicilon’s entire animal model library, including the tumor animal model to the world’s regional pharmaceutical industry counterparts.

Medicilon attaches great importance to the pharmaceutical research and development technology to make sure that we master the cutting edge techniques of this part.

Medicilon has attended a lot of large academic exchange meeting such as SAPA. Collaboration and win-win are our mission as well as our vision of globalization.

Medicilon has a complete animal model library, including more than 200 kinds of tumor models and 50 kinds of disease models available for domestic and foreign customers.

On the more popular models in recent years, such as orthotropic transplantation model, humanized tumor transplantation model, genetically modified model and etc., Medicilon’s current level of technology for them is mature and stable.

Followings are the part of contents from Dr. Wang Jun speech:

Xenograft Models (cellular therapy)

Syngeneic ModelsSyngeneic Mouse model (efficacy study)

PD studyFCM Data Analysis

FCM Phenotypic Analysis

FCM Panel Design

Pharmacology Services

other animal model at medicilonother animal models at medicilon

评论

此博客中的热门博文

What is preclinical testing?

In the process of  preclinical testing  of a compound or biological agent into a drug, the compound involved must go through the testing phase. First, we need to identify potential targets that can treat the disease. Then, a variety of compounds or preparations are screened out. Any compound that has shown potential as a drug for the treatment of this disease needs to be tested for toxicity before clinical testing to reduce the possibility of injury. preclinical testing What is the basis of preclinical testing? According to US Food and Drug Administration (FDA) regulations, a series of tests are required before a new drug is approved for use. In the first stage, basic research determines a hypothetical target for the treatment of a certain disease, and then screens small molecules or biological compounds to discover any substance with the potential to treat the disease. Then, a  preclinical research  phase followed, before which, as described above, the potential toxicity of the compou

Inventory of the three major in vitro pharmacokinetic research methods

  The metabolic properties of a compound are an essential factor in whether or not it can be used as a drug in the clinical setting, so pharmacokinetic studies of newly synthesized compounds are required in drug development. In vitro incubation with liver microsomes, recombinant CYP450 enzyme lines, and in vitro incubation with hepatocytes are some of the more common in vitro drug metabolism methods. 1. In vitro incubation method with liver microsomes The metabolic stability and metabolic phenotypes of candidate compounds in different species of liver microsomes are good predictors of the metabolic properties of compounds in vivo. They are practical tools for evaluating candidate compounds in the pre-development phase of drug development. Liver microsomes include rat liver microsomes, human liver microsomes, canine liver microsomes, monkey liver microsomes, and mouse liver microsomes. In in vitro incubation of the liver, microsomes are the "gold standard" for in vitro d

Enzyme Activity Assay Service

  Enzymatic assay Lance Assay Alphascreen Assay Z’-LYTE Assay Adapta Assay Kinase-Glo Assay ADP-Glo Assay Ligand Binding Assay ELISA Assay HTRF Assay Enzyme activity assays  are laboratory methods for measuring enzymatic activity. They are vital for the study of enzyme kinetics and enzyme inhibition. Enzyme units : Amounts of enzymes can either be expressed as molar amounts, as with any other chemical, or measured in terms of activity, in enzyme units. Medicilon provides various  enzyme activity assays  for  kinases , phosphatases, proteinases, deacetylase, peptidase, esterase, and other enzymes. Our line of well-characterized immunoassays and biochemical kits ensures accurate and reproducible results. Enzyme is a  large category of bio-molecules  that catalyze various biological processes including metabolic processes, cellular signaling and regulation, cell division and apoptosis. Enzymatic reactions convert substrate molecules into chemically modified molecules products with high sp