Medicilon's pharmacology models for inflammatory-immune diseases

Inflammatory immune diseases have gained much attention as the incidence has grown bigger each year. The diseases can affect many parts of human bodies and reduce the quality of life drastically. Yet the diagnoses can be frustrating and stressful because no one is sure what causes such diseases.

The preclinical pharmacology department of Medicilon has been deeply involved in this field for many years, and has provided a variety of stable and reliable animal models for different targets and pathways for the evaluation of inflammatory immune disease treatments in order for the successful clinical transformation.

❖ Medicilon's Inflammatory & Immune Diseases Models

At present, as the pathogenesis of inflammatory and immunological diseases is unclear, there are few effective therapeutic drugs available in clinical practice. In such a context, the appropriate preclinical research techniques and models are required to help companies and researchers further develop and evaluate new drugs. Our Preclinical Pharmacodynamics Department has been deeply involved in this field for years, developing reliable animal-based efficacy evaluation models aimed at different targets and pathways, thus facilitating the clinical transformation of new drugs.

RA, rheumatoid arthritis

RA is a chronic and systemic inflammatory autoimmune disease mainly targeting joints. It has a very high disability rate. The cause of the disease is still unclear.

Medicilon models that you can choose from:

CIA mice/rats Models
CFA rats Models

Major Endpoints

Foot Volume

△CIA Models △CFA Models

Arthritis Index

△CIA Models

Cytokine Expression

△CFA Models

Other arthritis models:

Carrageenan-induced acute arthritis mice/rats models

Uric acid sodium induced gouty arthritis rats models

"Leaky Gut" with Age Improved through Dietary Restriction

Altered Levels of Neonatal Inflammatory Markers Associated with Childhood Leukemia

Key Protein Mediating Inflammatory Response Discovered

EAE, experimental allergic encephalomyelitis

Psoriasis

Psoriasis is a common skin disease that occurs worldwide. It is a disease that is not only closely related to genetics, but also obviously related to the environment.

Medicilon establishes diverse models that captures key features of psoriasis, including:

IL-23 induced hyperplasia of auricle epidermis mice models
Imiquimod induced psoriasis mice models
Vaginal epithelial mitosis mice models
Tale exfoliation mice models

Major Endpoints:

Skin thickness

△Pathological skin change of Imiquimod induced psoriasis mice

Ear thickness

△Pathological skin change of IL-23 induced psoriasis mice

Skin colligation score of mice

△Pathological skin change of Imiquimod induced psoriasis mice

Pathological skin score

△Imiquimod induced psoriasis △IL-23 induced psoriasis

AD, atopic dermatitis

Atopic dermatitis is a chronic, recurring, inflammatory skin disease, often accompanied by other symptoms such as allergic rhinitis, asthma, eczema, etc. The cause of the disease is not yet clear and there is no cure.

The disease related models include:

DNFB induced chronic dermatitis mice models
DNFB & OX induced chronic dermatitis mice models
Phorbol ester induced acute eczema mice models
DNFB induced acute eczema mice models

Skin score

△DNFB induced chronic dermatitis

Skin thickness

△DNFB induced chronic dermatitis

IBD, Infectious Bursal Disease

Inflammatory bowel disease (IBD) is a group of unexplained chronic intestinal inflammatory diseases. Due to the increasing incidence, it has become a common digestive system disease in our country. It mainly refers to ulcerative colitis and Crohn’s Disease.

Our IBD models includes:

TNBS induced IBD rats models

DSS induced IBD mice models

△Colon length of TNBS induced IBD rats models

△Colon weight of DSS induced IBD mice models

Medicilon and Binhui Biopharmaceutical Have Reached a Strategic Collaboration to Jointly Draw a New Blueprint for the Development of New Biological Drugs

On March 18, Medicilon and Binhui Biopharmaceutical (Binui Bio) announced a strategic collaboration. The two parties will work together to jointly explore the possibilities in cutting-edge fields such as oncolytic viruses, nucleic acid drugs and protein drugs. Gather and Work Together to Create Advantages Facilitate the Research and Development of Oncolytic Viruses, Nucleic Acids, Proteins and Other Drugs As a one-stop biopharmaceutical comprehensive preclinical R&D service CRO, Medicilon has been developing and accumulating for 20 years, always adhering to the spirit of innovation, and has successfully constructed bi/multi-specific antibodies, ADCs , mRNA vaccines , small nucleic acid drugs , PROTAC , and CGT technical service platform that have helped 421 INDs obtain clinical approval. It is this outstanding achievement that has earned Medicilon wide recognition in the industry and laid a solid foundation f...

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A Nickel-Catalyzed Reductive Alkylation of Aryl Bromides and Chlorides for Sp3-Sp2 Bond Formation

In 2012, a nickel-catalyzed reductive alkylation method of aryl bromides and chlorides was reported. Under the optimized conditions, a variety of aryl and vinyl bromides as well as active aryl chloride can be reductively coupled with alkyl bromides in high yields. The protocols were highly functional-group tolerant and the reactions were not air or moisture sensitive. The reaction showed different chemoselectivity than conventional cross-coupling reactions. Substrates bearing both anelectrophilic and nucleophilic carbon resulted in selective coupling at the electrophilic carbon (R-X) and no reaction occurred at the nucleophilic carbon (R-[M]). The 2010 Nobel Prize in Chemistry was awarded for the Pd-catalyzed cross-coupling, and in the past decade the progress in cross-coupling has not only had a significant impact on academic research but has also influenced the industrial synthetic application. The transition-metal-catalyzed union of nucleophilic organo-boronic acids with elect...

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What is Toxicokinetics?

Toxicokinetics is essentially the study of “how a substance gets into the body and what happens to it in the body”. Four processes are involved in toxicokinetics. The study of the kinetics (movement) of chemicals was originally conducted with pharmaceuticals and thus the term pharmacokinetics became commonly used. In addition, toxicology studies were initially conducted with drugs. However, the science of toxicology has evolved to include environmental and occupational chemicals as well as drugs. Toxicokinetics is thus the appropriate term for the study of the kinetics of all toxic substances. Frequently the terms toxicokinetics , pharmacokinetics , or disposition may be found in the literature to have the same meaning. Disposition is often used in place of toxicokinetics to describe the time-course of movement of chemicals through the body (that is, how does the body dispose of a xenobiotic?). The disposition of a toxicant along with its’ biological reactivi...

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